A thick dentin layer forms the bulk of dental mineralized dental tissues. Dentin is capped by
a crown made of highly mineralized and protective enamel, and in the root, it is covered by …

The adult skeleton is a metabolically active organ system that undergoes continuous
remodeling to remove old and/or stressed bone (resorption) and replace it with new bone …

Several genetic disorders affecting bone mineralization may manifest during dentin
mineralization. Dentin and bone are similar in several aspects, especially pertaining to the …

Root canal therapy has been the predominant approach in endodontic treatment, wherein
the entire pulp is cleaned out and replaced with a gutta‐percha filling. However, living pulp …

A deletion mutation called fro (fragilitas ossium) in the murine Smpd3 (sphingomyelin
phosphodiesterase 3) gene leads to a severe skeletal dysplasia. Smpd3 encodes a neutral …

Osteoporosis and its associated fractures are highly prevalent in older women. Recent
studies have shown that gut microbiota play important roles in regulating bone metabolism …

Wnt signalling is a key pathway controlling bone formation in mice and humans. One of the
regulators of this pathway is Dkk1, which antagonizes Wnt signalling through the formation …

Since the discovery of bioactive molecules sequestered in dentine, researchers have been
exploring ways to harness their activities for dental regeneration. One specific area …

Understanding how the material properties of bone tissue from the various forms of
osteogenesis imperfecta (OI) differ will allow us to tailor treatment regimens for affected …

The human skeleton is a metabolically active system that is constantly regenerating via the
tightly regulated and highly coordinated processes of bone resorption and formation …