Herein, we report the development of an integrated continuous manufacturing (CM) process
for the penultimate step in the synthesis of apremilast, the drug substance (DS) of the …

A scalable continuous manufacturing process for the synthesis and crystallization of form III
carbamazepine (CBZ) from iminostilbene (ISB) has been established. A high-yielding …

This is Part II of a series on the development and characterization of an integrated
continuous manufacturing (CM) process developed for the penultimate step in the synthesis …

Crystallization is an important unit operation in pharmaceutical drug substance
manufacturing for the isolation of organic products. Impurity control is a recurring critical …

Phosphonamidate 1 is a key fragment in the assembly of rovafovir etalafenamide, a novel
nucleotide reverse transcriptase inhibitor under development at Gilead Sciences for the …

Organophosphorus compounds such as phosphonamidates are gaining attention across
different fields of chemistry, with interesting applications as pharmaceuticals, or pesticides …

Fluorinated nucleoside 1 is a key starting material in the synthesis of rovafovir etalafenamide
(2), a novel nucleotide reverse transcriptase inhibitor under development at Gilead Sciences …

As part of the synthesis of rovafovir etalafenamide, the development and manufacturing-
scale demonstration of a dioxirane-mediated oxidative elimination is described. The reaction …

Identification and control of impurities play a critical role in chemical process development
for drug substance synthesis. Most chemical reactions result in a number of by-products and …

Simply, production of a drug needs two main steps; the first step is the chemical synthesis,
and the second one is the pharmaceutical analysis. At the first step, the desired drug must …