Abstract The leaf of Pangi (Pangium edule) is used as food in North Sulawesi. According to
a study conducted in vitro, Pangi leaf extract suppressed the replication of the human …

Human immunodeficiency virus is responsible for acquired immunodeficiency syndrome
(AIDS), an infectious disease that consists a serious concern worldwide for more than three …

Nelfinavir (Viracept®) was originally designed as a specific HIV protease inhibitor and, since
its introduction in 1997, has served as an effective, reliable, and well-tolerated HIV drug …

A novel class of HIV-1 protease inhibitors with flexible piperidine as the P2 ligand was
designed with the aim of improving extensive interactions with the active subsites. Many …

Drug design and drug discovery is a passionate, prolonged, and inter-disciplinary multistep
process. The traditional drug discovery process is costly and time-consuming which …

Upon the basis of both possible ligand-binding site interactions and the uniformity of key
residues in active sites, a novel class of HIV-1 PR/RT dual inhibitors was designed and …

HIV-1 protease is a crucial enzyme for the life cycle of the human immunodeficiency virus,
the retrovirus that triggers AIDS. It is well documented that HIV-1 protease mediates the …

The Human Immunodeficiency Virus type 1 protease enzyme (HIV-1 PR) is one of the most
important targets of antiretroviral therapy used in the treatment of AIDS patients. The success …

Flexible heterocyclic moieties as the P2 ligands of HIV-1 protease inhibitors may be adapted
to the minimally distorted active site of mutations easily and enhance activity against DRV …

Full article: Indolizine Studies, Part 5: Indolizine-2-carboxamides as Potential HIV-1 Protease
Inhibitors[ 1 ] Skip to Main Content Taylor and Francis Online homepage Taylor and Francis …