Cerebral postischemic reperfusion injury is defined as deterioration of ischemic brain tissue
that parallels and antagonizes the benefits of restoring cerebral circulation after therapeutic …

Neuroprotection and brain repair in patients after acute brain damage are still major
unfulfilled medical needs. Pharmacological treatments are either ineffective or confounded …

Despite numerous defenses, the brain is vulnerable to oxidative stress resulting from
ischemia/reperfusion. Excitotoxic stimulation of superoxide and nitric oxide production leads …

Isoflurane (ISO) is the most commonly used inhalational anesthetic for experimental
interventions in mice and is preferred for imaging technologies that require the mouse to …

Stroke is among the most frequent causes of death and adult disability, especially in highly
developed countries. However, treatment options to date are very limited. To meet the need …

Animals exposed to brief periods of moderate hypoxia (8% to 10% oxygen for 3 hours) are
protected against cerebral and cardiac ischemia between 1 and 2 days later. This hypoxia …

Cerebral ischemia triggers acute inflammation, which exacerbates primary brain damage.
Activation of the innate immune system is an important component of this inflammatory …

This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia
and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and …

Brain ischemia is one of the most common causes of death and the leading cause of adult
disability in the world. Brain ischemic preconditioning (BIP) refers to a transient, sublethal …

Background. The concept of ischaemic preconditioning was introduced in the late 1980s.
The concept emerged that a brief subcritical ischaemic challenge could mobilize intrinsic …