Abstract Nuclear erythroid 2-related factor 2 (Nrf2) is a central regulator of antioxidative
response elements-mediated gene expression. It has a significant role in adaptive …

The skin is frequently exposed to environmental challenges, such as UV irradiation, toxic
chemicals, and mechanical wounding. These insults cause an increase in the levels of …

Fumarates improve multiple sclerosis (MS) and psoriasis, two diseases in which both IL-12
and IL-23 promote pathogenic T helper (Th) cell differentiation. However, both diseases …

In vitro tests are needed to replace animal tests to screen for the skin sensitization potential
of chemicals. Skin sensitizers are electrophilic molecules and the Nrf2-electrophile-sensing …

To better understand the role of transcription factor NF-E2-related factor (NRF) 2 in the
human and its contribution to cancer chemoprevention, we have knocked down its negative …

Multiple sclerosis (MS) is an autoimmune disease characterized by peripheral activation of
CD4+ T cells that migrate into the central nervous system (CNS) and mount an autoimmune …

Solar ultraviolet (UV) radiation is an important environmental factor that leads to immune
suppression, inflammation, photoaging, and skin carcinogenesis. Here, we reviewed the …

Purpose Excessive exposure of skin to solar radiation is associated with greatly increased
production of reactive oxygen and nitrogen species (ROS, RNS) resulting in oxidative stress …

As the elderly population increases, a growing number of individuals suffer from age‐
associated neurodegenerative diseases, such as A lzheimer's disease (AD) and P …

The skin barrier and its endogenous protective mechanisms cope daily with exogenous
stressors, of which ultraviolet radiation (UVR) poses an imminent danger. Although the skin …