Highly perturbed pKa values in the unfolded state of hen egg white lysozyme

J Bradley, F O'Meara, D Farrell, JE Nielsen - Biophysical journal, 2012 - cell.com
The majority of pK a values in protein unfolded states are close to the amino acid model pK
a values, thus reflecting the weak intramolecular interactions present in the unfolded …

Constructing and evaluating predictive models for protein biophysical characteristics

MA Johnston, JE Nielsen - Annual Reports in Computational Chemistry, 2011 - Elsevier
A central aim of computational biology is the prediction of experimentally observable
biophysical characteristics of proteins. In the past decade, a large number of tools have …

Calcium and its Protein Binding in Lactation in Mammary Gland and Blood Clotting

DK Awasthi, M Kamal - International Research Journal of …, 2021 - search.proquest.com
Ca 2+ ions are central to a complex intracellular messenger system that is mediating a wide
range of biological processes: muscle contraction, secretion, glycolysis and …

A collaborative environment for developing and validating predictive tools for protein biophysical characteristics

MA Johnston, D Farrell, JE Nielsen - Journal of computer-aided molecular …, 2012 - Springer
The exchange of information between experimentalists and theoreticians is crucial to
improving the predictive ability of theoretical methods and hence our understanding of the …

[PDF][PDF] Engineering Enzyme Stability and Catalysis: A Case Study of Hen Egg White Lysozyme

FOMBA Mod - 2013 - researchgate.net
The ability to engineer enzymes is of great importance both as a critical test of our
understanding of the biochemistry involved and for practical applications in biotechnology …