[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Toxicity of metal-based nanoparticles: Challenges in the nano era

N Zhang, G Xiong, Z Liu - Frontiers in Bioengineering and …, 2022 - frontiersin.org
With the rapid progress of nanotechnology, various nanoparticles (NPs) have been
applicated in our daily life. In the field of nanotechnology, metal-based NPs are an important …

Prospects and hazards of silica nanoparticles: Biological impacts and implicated mechanisms

R Ding, Y Li, Y Yu, Z Sun, J Duan - Biotechnology Advances, 2023 - Elsevier
With the thrive of nanotechnology, silica nanoparticles (SiNPs) have been extensively
adopted in the agriculture, food, cosmetic, and even biomedical industries. Due to the mass …

Rational design of nanocarriers for mitochondria-targeted drug delivery

L Huang, Z Sun, Q Shen, Z Huang, S Wang… - Chinese Chemical …, 2022 - Elsevier
Well-developed mitochondria-targeted nanocarriers for function regulation are highly
desirable. Numerous studies have been conducted on the treatment of mitochondria-related …

Use of silica nanoparticles for drug delivery in cardiovascular disease

H Kirla, DJ Henry, S Jansen, PL Thompson… - Clinical …, 2023 - Elsevier
Purpose Cardiovascular disease (CVD) is the leading cause of death worldwide. The
current CVD therapeutic drugs require long-term treatment with high doses, which increases …

Toxicity mechanism of nanomaterials: Focus on endoplasmic reticulum stress

B Li, T Zhang, M Tang - Science of the Total Environment, 2022 - Elsevier
Over the years, although the broad application of nanomaterials has not brought
convenience to people's life, growing concern surrounds their safety. Recently, much …

Nanomaterials-induced toxicity on cardiac myocytes and tissues, and emerging toxicity assessment techniques

Y Cheng, Z Chen, S Yang, T Liu, L Yin, Y Pu… - Science of The Total …, 2021 - Elsevier
The extensive production and use of nanomaterials have resulted in the continuous release
of nano-sized particles into the environment, and the health risks caused by exposure to …

Amifostine attenuates bleomycin-induced pulmonary fibrosis in mice through inhibition of the PI3K/Akt/mTOR signaling pathway

W Yang, L Pan, Y Cheng, X Wu, S Huang, J Du… - Scientific Reports, 2023 - nature.com
Amifostine is a normal cell protection agent, not only used in the adjuvant therapy of lung
cancer, ovarian cancer, breast cancer, nasopharyngeal cancer, bone tumor, digestive tract …

Amorphous silica nanoparticles caused lung injury through the induction of epithelial apoptosis via ROS/Ca2+/DRP1-mediated mitochondrial fission signaling

Y Li, Y Zhu, B Zhao, Q Yao, H Xu, S Lv, J Wang… - …, 2022 - Taylor & Francis
The adverse effects of amorphous silica nanoparticles (SiNPs) exposure on the respiratory
system were increasingly recognized, however, its potential pathogenesis still remains not …

Advances in the study of silica nanoparticles in lung diseases

LH Ao, YG Wei, HR Tian, H Zhao, J Li… - Science of the Total …, 2024 - Elsevier
Silicon dioxide nanoparticles (SiNPs) are one of the major forms of silicon dioxide and are
composed of the most-abundant compounds on earth. Based on their excellent properties …