Cushing's syndrome: Overview of clinical presentation, diagnostic tools and complications

M Barbot, M Zilio, C Scaroni - … practice & research Clinical endocrinology & …, 2020 - Elsevier
Cushing's syndrome (CS) is a severe condition that results from chronic exposure to
elevated circulating cortisol levels; it is a rare but potentially life-threating condition …

Hypercoagulability and risk of venous thromboembolic events in endogenous Cushing's syndrome: a systematic meta-analysis

J Wagner, F Langlois, DST Lim, S McCartney… - Frontiers in …, 2019 - frontiersin.org
Background: Hypercortisolism has been implicated in the development of venous
thromboembolic events (VTE). We aimed to characterize VTE risk in endogenous Cushing's …

Hypercoagulability in C ushing's syndrome: prevalence, pathogenesis and treatment

R van der Pas, FWG Leebeek, LJ Hofland… - Clinical …, 2013 - Wiley Online Library
Cushing's syndrome is not only accompanied by an increased prevalence of cardiovascular
disease but also by a hypercoagulable state that is reflected by an increased incidence of …

Epidemiology and pathophysiology of venous thromboembolism: similarities with atherothrombosis and the role of inflammation

N Riva, MP Donadini, W Ageno - Thrombosis and haemostasis, 2015 - thieme-connect.com
Venous thromboembolism (VTE) is a multifactorial disease. Major provoking factors (eg
surgery, cancer, major trauma, and immobilisation) are identified in 50–60% of patients …

Immunomodulatory drugs and their application to the management of canine immune‐mediated disease

NT Whitley, MJ Day - Journal of Small Animal Practice, 2011 - Wiley Online Library
This review summarises the current understanding of immune response and T cell subsets
in the context of development of autoimmunity in the dog. Mode of action and rational usage …

Impact of acute and chronic stress on thrombosis in healthy individuals and cardiovascular disease patients

L Sandrini, A Ieraci, P Amadio, M Zarà… - International journal of …, 2020 - mdpi.com
Psychological stress induces different alterations in the organism in order to maintain
homeostasis, including changes in hematopoiesis and hemostasis. In particular, stress …

Mechanisms in endocrinology: the spectrum of haemostatic abnormalities in glucocorticoid excess and defect

AM Isidori, M Minnetti, E Sbardella… - European journal of …, 2015 - academic.oup.com
Glucocorticoids (GCs) target several components of the integrated system that preserves
vascular integrity and free blood flow. Cohort studies on Cushing's syndrome (CS) have …

Changes in coagulation indexes and occurrence of venous thromboembolism in patients with Cushing's syndrome: results from a prospective study before and after …

L Manetti, F Bogazzi, C Giovannetti… - European Journal of …, 2010 - academic.oup.com
Objectives To evaluate whether patients with Cushing's syndrome (CS) had i) changes in
coagulative and fibrinolytic parameters associated with CS activity and ii) higher prevalence …

Adverse effects of glucocorticoids: coagulopathy

MCA Coelho, CV Santos, LV Neto… - European Journal of …, 2015 - academic.oup.com
Hypercortisolism is associated with various systemic manifestations, including central
obesity, arterial hypertension, glucose intolerance/diabetes mellitus, dyslipidemia …

Adipose tissue‐derived plasminogen activator inhibitor‐1 function and regulation

H Kaji - Comprehensive Physiology, 2011 - Wiley Online Library
Adipose tissue has recently been reevaluated as an endocrine organ, and adipose‐tissue‐
derived endocrine factors are termed adipokines. Plasminogen activator inhibitor‐1 (PAI‐1) …