Management of diabetic kidney disease (DKD) has evolved in parallel with our growing
understanding of the multiple interrelated pathophysiological mechanisms that involve …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected. Although
AKI-to-CKD transition has been intensively studied, the information of AKI on CKD is very …

Results From weeks 3 to 130, there was a 66% difference in the mean rate of eGFR decline
with canagliflozin versus placebo (mean slopes,− 1.30 versus− 3.83 ml/min per 1.73 m 2 per …

Increasing evidence has demonstrated the bidirectional link between acute kidney injury
(AKI) and chronic kidney disease (CKD) such that, in the clinical setting, the new concept of …

The landscape of kidney disease in diabetes has shifted. The classical dogma of “diabetic
nephropathy” progressing through stages of albuminuria, leading to decline in glomerular …

Unilateral ischemia-reperfusion (UIR) injury leads to progressive renal atrophy and
tubulointerstitial fibrosis (TIF) and is commonly used to investigate the pathogenesis of the …

Abstract Ischemia-reperfusion (I/R) is considered the primary cause of acute kidney injury
and is higher among older individuals. Although ischemic episodes are hard to predict and …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are increasingly recognized as
interconnected conditions with overlapping pathophysiological mechanisms. This review …

Acute kidney injury leading to chronic kidney disease through tubulointerstitial fibrosis is a
major challenge in nephropathy. Several signaling pathways promote interstitial fibrosis; …

Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an
effector responsible for apoptosis execution, is activated within the peritubular capillary …