Context.—Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder of
immune regulation that can eventually result in end-organ damage and death. HLH is …

Hemophagocytic lymphohistiocytosis (HLH) is an unusual syndrome characterized by fever,
splenomegaly, jaundice, and the pathologic finding of hemophagocytosis (phagocytosis by …

Hemophagocytic lymphohistiocytosis (HLH) comprises familial (primary) hemophagocytic
lymphohistiocytosis (FHL) and secondary HLH (SHLH), both clinically characterized by …

Familial hemophagocytic lymphohistiocytosis (FHL) is a rare, rapidly fatal, autosomal
recessive immune disorder characterized by uncontrolled activation of T cells and …

Secretion of cytolytic granules content at the immunological synapse is a highly regulated
process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of …

Rapid intracellular transport and secretion of cytotoxic granules through the immunological
synapse requires a balanced interaction of several proteins. Disturbance of this highly …

Familial hemophagocytic lymphohistiocytosis (FHL) is a rare autosomal recessive disorder
characterized by hyperactive phagocytes and defects in natural killer cell function. It has …

Shanmuganathan Chandrakasan, MD, and Alexandra H. Filipovich, MD Hemophagocytic
lymphohistiocytosis (HLH) is a potentially life-threatening disorder characterized by immune …

Epstein–Barr virus (EBV) is the major triggering factor producing hemophagocytic syndrome
or hemophagocytic lymphohistiocytosis (HLH). In this review, diagnostic problems, clinical …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by extreme
immune activation, resulting in pathologic inflammation. The diagnosis includes a spectrum …