Clinical translation of nanomedicines: Challenges, opportunities, and keys

MA Younis, HM Tawfeek, AAH Abdellatif… - Advanced drug delivery …, 2022 - Elsevier
Despite the massive interest and recent developments in the field of nanomedicine, only a
limited number of formulations have found their way to the clinics. This shortcoming reveals …

Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines

T Nakamura, Y Sato, Y Yamada… - Advanced drug delivery …, 2022 - Elsevier
A new era of nanomedicines that involve nucleic acids/gene therapy has been opened after
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …

Mucoadhesive formulations: Innovations, merits, drawbacks, and future outlook

A Kumar, PK Naik, D Pradhan, G Ghosh… - Pharmaceutical …, 2020 - Taylor & Francis
Mucosa has now been recognized as a potential site for both local and systemic delivery of
therapeutics. Mucoadhesive drug delivery systems with customizable release profiles have …

Chitosan-capped silver nanoparticles with potent and selective intrinsic activity against the breast cancer cells

AAH Abdellatif, A Abdelfattah, MA Younis… - Nanotechnology …, 2023 - degruyter.com
Herein, we report on the development of chitosan-capped silver nanoparticles (AgNPs-CHI)
with an intrinsic activity against breast cancer cells. Following chemical synthesis via a …

Impact of the functional coating of silver nanoparticles on their in vivo performance and biosafety

HM Tawfeek, MA Younis, BN Aldosari… - Drug Development …, 2023 - Taylor & Francis
Objective and significance Silver nanoparticles (AgNPs) have become an interesting
therapeutic modality and drug delivery platform. Herein, we aimed to investigate the impact …

Nanoformulations in the treatment of lung cancer: current status and clinical potential

MA Younis, MA Alsogaihi, AAH Abdellatif… - Drug Development …, 2024 - Taylor & Francis
Objective Recent developments in nanotechnology have regained hope in enabling the
eradication of lung cancer, while overcoming the drawbacks of the classic therapeutics …

Enhancing the low oral bioavailability of sulpiride via fast orally disintegrating tablets: formulation, optimization and in vivo characterization

H M. Tawfeek, YA Hassan, MF Aldawsari, M H. Fayed - Pharmaceuticals, 2020 - mdpi.com
Sulpiride (SUL) is a dopamine D2-receptor antagonist used for management of GIT
disturbance and it has anti-psychotic activities based on the administered dose. SUL …

One‐pot synthesis of fluorescent nitrogen and sulfur–carbon quantum dots as a sensitive nanosensor for trimetazidine determination

F Belal, M Mabrouk, S Hammad, A Barseem… - …, 2021 - Wiley Online Library
Water‐soluble and highly stable N, S‐doped CQDs (N, S‐CQDs) were synthesized using a
low‐cost strategy with citric acid and thiosemicarbazide in one step for use as a fluorescent …

Implementation of Quality by Design of Sublingual Antihypertensive Drugs

D Joshi, NK Choudhary - Journal of Pharmaceutical Innovation, 2024 - Springer
Background Hypertension poses a global health challenge, contributing significantly to
mortality and cardiovascular diseases in both developed and low-to middle-income nations …

Implementing Quality by Design for Development and Optimization of Sublingual Tablet of Valsartan

D Joshi, NK Choudhary - Journal of Pharmaceutical Innovation, 2024 - Springer
Purpose Heart failure, a progressive cardiovascular disorder, significantly affects patient
morbidity and mortality. Valsartan, an angiotensin II receptor antagonist, is widely used to …