In native states, animal cells of many types are supported by a fibrous network that forms the
main structural component of the ECM. Mechanical interactions between cells and the 3D …

Fibrous networks are essential structural components of biological and engineered
materials. Accordingly, many approaches have been developed to quantify their structural …

Although it is widely appreciated that cells migrate in a variety of diverse environments in
vivo, we are only now beginning to use experimental workflows that yield images with …

When cells come in contact with an adhesive matrix, they begin to spread and migrate with a
speed that depends on the stiffness of the extracellular matrix. On a flat surface, migration …

The pore size of biopolymer networks governs their mechanical properties and strongly
impacts the behavior of embedded cells. Confocal reflection microscopy and second …

This study evaluated three techniques, stimulated emission depletion (STED) microscopy,
atomic force microscopy (AFM), and cryogenic scanning electron microscopy (Cryo-SEM) …

Collagen accounts for the major extracellular matrix (ECM) component in many tissues and
provides mechanical support for cells. Magnetic Resonance (MR) Imaging, MR based …

Cell motility under physiological and pathological conditions including malignant
progression of cancer and subsequent metastasis are founded on environmental …

The structural features of the matrix surrounding the cells play a crucial role in regulating
their behavior. Here, we used fluorescence microscopy and customized analysis algorithms …

When sheared, most elastic solids including metals, rubbers, and polymer gels dilate
perpendicularly to the shear plane. This behavior, known as the Poynting effect, is …