The role of STATs in ovarian cancer: exploring their potential for therapy
D Standing, E Feess, S Kodiyalam, M Kuehn, Z Hamel… - Cancers, 2023 - mdpi.com
Simple Summary Ovarian cancer remains the deadliest cancer of the female reproductive
system. There is a significant body of evidence that has demonstrated that Signal …
system. There is a significant body of evidence that has demonstrated that Signal …
Chitosan-coated artesunate protects against ulcerative colitis via STAT6-mediated macrophage M2 polarization and intestinal barrier protection
Y Tao, L Xu, X Liu, P Wang, S Wei, Y Huang… - International Journal of …, 2024 - Elsevier
Oral delivery of chitosan-coated artesunate (CPA) has been proven to be effective at
preventing ulcerative colitis (UC) in mice. However, the anti-inflammatory mechanism is not …
preventing ulcerative colitis (UC) in mice. However, the anti-inflammatory mechanism is not …
STATs, Promising Targets for the Treatment of Autoimmune and Inflammatory Diseases
X He, P Liu, Y Luo, X Fu, T Yang - European Journal of Medicinal Chemistry, 2024 - Elsevier
Cytokines play a crucial role in the pathophysiology of autoimmune and inflammatory
diseases, with over 50 cytokines undergoing signal transduction through the Signal …
diseases, with over 50 cytokines undergoing signal transduction through the Signal …
miR-126 promotes M1 to M2 macrophage phenotype switching via VEGFA and KLF4
Background Macrophage polarization and microRNA play crucial roles in the development
of atherosclerosis (AS). The M1 macrophage phenotype contributes to the formation of …
of atherosclerosis (AS). The M1 macrophage phenotype contributes to the formation of …
Human Tendon‐on‐a‐Chip for Modeling the Myofibroblast Microenvironment in Peritendinous Fibrosis
RE Ajalik, I Linares, RG Alenchery… - Advanced …, 2024 - Wiley Online Library
Understanding the myofibroblast microenvironment is critical to developing therapies for
fibrotic diseases. Here the development of a novel human tendon‐on‐a‐chip (hToC) is …
fibrotic diseases. Here the development of a novel human tendon‐on‐a‐chip (hToC) is …
S100A9 deletion in microglia/macrophages ameliorates brain injury through the STAT6/PPARγ pathway in ischemic stroke
X Liu, J Wang, J Jin, Q Hu, T Zhao… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Microglia and infiltrated macrophages (M/M) are integral components of the
innate immune system that play a critical role in facilitating brain repair after ischemic stroke …
innate immune system that play a critical role in facilitating brain repair after ischemic stroke …
Alpha-galactosylceramide pre-treatment attenuates clinical symptoms of LPS-induced acute neuroinflammation by converting pathogenic iNKT cells to anti …
TC Kim, HJ Park, SW Lee, YH Park, L Van Kaer… - Inflammation …, 2024 - Springer
Background Invariant natural killer T (iNKT) cells play protective or pathogenic roles in a
variety of immune and inflammatory diseases. However, whether iNKT cells contribute to the …
variety of immune and inflammatory diseases. However, whether iNKT cells contribute to the …
Sesquiterpene from Artemisia argyi seed extracts: A new anti-acute peritonitis agent that suppresses the MAPK pathway and promotes autophagy
Y Li, Y Wang, T Li, Z Li, T Guo, G Xue, Y Duan… - …, 2024 - Springer
To find novel anti-inflammatory drugs, we screened anti-inflammatory compounds from 18
different types of Artemisia argyi seed extracts. The in vitro and in vivo anti-inflammatory …
different types of Artemisia argyi seed extracts. The in vitro and in vivo anti-inflammatory …
Zymosan-induced murine peritonitis is associated with an increased sphingolipid synthesis without changing the long to very long chain ceramide ratio
A Pierron, L Guzylack-Piriou, D Tardieu… - International Journal of …, 2023 - mdpi.com
Sphingolipids are key molecules in inflammation and defense against pathogens. Their role
in dectin-1/TLR2-mediated responses is, however, poorly understood. This study …
in dectin-1/TLR2-mediated responses is, however, poorly understood. This study …
Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABL
R Qin, T Wang, W He, W Wei, S Liu, M Gao… - Cell Communication and …, 2023 - Springer
Abstract Background The Philadelphia chromosome encodes the BCR-ABL fusion protein,
which has two primary subtypes, P210 and P190. P210 and P190 cause Philadelphia …
which has two primary subtypes, P210 and P190. P210 and P190 cause Philadelphia …