The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

Figure 2. Regulation of the Rho GTPase cycle. Rho protein cycle between an inactive GDP-
bound and an active GTP-bound state. Inhibition of the mevalonate synthesis by statins …

Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell
functions and oncogenesis. Here we report that miR-133 has a critical role in determining …

Aim Vascular endothelium plays a role in capillary transport of nutrients and drugs and
regulates angiogenesis, homeostasis, as well as vascular tone and permeability as a major …

Rationale: NADPH oxidases are a major source of superoxide (O2−) in the cardiovascular
system. The function of Nox4, a member of the Nox family of NADPH oxidases, in the heart is …

Statins are 3-hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase inhibitors, which
are prescribed extensively for cholesterol lowering in the primary and secondary prevention …

The HMG Co-enzyme inhibitors and new lipid-modifying agents expand their new
therapeutic target options in the field of medical profession. Statins have been described as …

Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

Increases in arginase activity have been reported in a variety of disease conditions
characterized by vascular dysfunction. Arginase competes with NO synthase for their …

Large-scale heterozygous deletions are a hallmark of cancer genomes. The concomitant
loss of multiple genes creates vulnerabilities that are impossible to reveal through the study …