Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …

Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …

The majority of oncogenic drivers are intracellular proteins, thus constraining their
immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual …

There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …

Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …

Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly
for hematologic malignancies. To date, however, genomic biomarkers to direct clinical …

The majority of oncogenic drivers are intracellular proteins, constraining their
immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual …

Neuroblastoma is a childhood cancer that can be inherited, but the genetic aetiology is
largely unknown. Here we show that germline mutations in the anaplastic lymphoma kinase …

Recent genomic and biological studies of neuroblastoma have shed light on the dramatic
heterogeneity in the clinical behaviour of this disease, which spans from spontaneous …

Background: Congenital central hypoventilation syndrome (CCHS) is characterized by
alveolar hypoventilation and autonomic dysregulation. Purpose:(1) To demonstrate the …