Importance Previous randomized clinical trials (RCTs) have supported the use of
endovascular therapy (EVT) in late-window acute ischemic stroke (AIS; 6-24 hours) …

The collateral circulation plays a crucial role in maintaining perfusion to brain tissue in
ischemic stroke, which prolongs the time window for effective therapies to be provided and …

Advances in acute ischemic stroke (AIS) treatment have been contingent on innovations in
neuroimaging. Neuroimaging plays a pivotal role in the diagnosis and prognosis of ischemic …

Background Recent clinical trials investigating endovascular therapy in the extended time
window have opened new treatment paradigms for patients with late‐presenting large …

Background While recent studies suggest a benefit of mechanical thrombectomy (MT) for the
treatment of patients with isolated large vessel occlusions presenting after 24 hours from the …

Background Ischemic stroke still ranks as the most fatal disease worldwide. Blood-brain
barrier (BBB) is a promising therapeutic target for protection. Brain microvascular endothelial …

Background Recent clinical trials have shown that mechanical thrombectomy is superior to
medical management for large vessel occlusion for up to 24 hours from onset. Our objective …

Objective To evaluate the role of endovascular thrombectomy in patients presenting with
acute ischemic stroke (AIS) due to large vessel occlusion in the very late window (> 24 …

Background While intravenous thrombolysis is recommended for patients who had an acute
ischaemic stroke (AIS) within 4.5 hours of symptom onset, there are few randomised trials …

Background Different studies have demonstrated the benefit of endovascular treatment
(EVT) up to 24 hours after acute ischemic stroke (AIS) onset. Recent cohort observational …