GSK‐3β at the Intersection of Neuronal Plasticity and Neurodegeneration

T Jaworski, E Banach-Kasper, K Gralec - Neural plasticity, 2019 - Wiley Online Library
In neurons, Glycogen Synthase Kinase‐3β (GSK‐3β) has been shown to regulate various
critical processes underlying structural and functional synaptic plasticity. Mouse models with …

Akt/GSK3 signaling in the action of psychotropic drugs

JM Beaulieu, RR Gainetdinov… - Annual review of …, 2009 - annualreviews.org
Psychotropic drugs acting on monoamine neurotransmission are major pharmacological
treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar …

The Akt–GSK-3 signaling cascade in the actions of dopamine

JM Beaulieu, RR Gainetdinov, MG Caron - Trends in pharmacological …, 2007 - cell.com
Drugs that act on dopamine neurotransmission are important tools for the management of
multiple neuropsychiatric disorders. Classically, dopamine receptors have been shown to …

MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders

AH Kim, M Reimers, B Maher, V Williamson… - Schizophrenia …, 2010 - Elsevier
MicroRNAs (miRNAs) are a large family of small non-coding RNAs which negatively control
gene expression at both the mRNA and protein levels. The number of miRNAs identified is …

Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia

TA Greenwood, LC Lazzeroni… - American Journal of …, 2011 - Am Psychiatric Assoc
Objective: The authors used a custom array of 1,536 single-nucleotide polymorphisms
(SNPs) to interrogate 94 functionally relevant candidate genes for schizophrenia and identify …

AKT/GSK3 signaling pathway and schizophrenia

ES Emamian - Frontiers in molecular neuroscience, 2012 - frontiersin.org
Schizophrenia is a prevalent complex trait disorder manifested by severe neurocognitive
dysfunctions and lifelong disability. During the past few years several studies have provided …

Molecular mechanisms of schizophrenia

UE Lang, I Puls, DJ Müller, N Strutz-Seebohm… - Cellular Physiology and …, 2007 - karger.com
Schizophrenia is a complex disorder, where family, twin and adoption studies have been
demonstrating a high heritability of the disease and that this disease is not simply defined by …

Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in …

AJ Law, JE Kleinman, DR Weinberger… - Human molecular …, 2007 - academic.oup.com
Abstract The neuregulin 1 (NRG1) receptor, ErbB4, has been identified as a potential risk
gene for schizophrenia. HER4/ErbB4 is a receptor tyrosine kinase whose transcript …

mTOR-related brain dysfunctions in neuropsychiatric disorders

L Ryskalin, F Limanaqi, A Frati, CL Busceti… - International journal of …, 2018 - mdpi.com
The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine
kinase, which senses and integrates several intracellular and environmental cues to …

Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia

A Mohammadi, E Rashidi, VG Amooeian - Psychiatry research, 2018 - Elsevier
Over the last decade, finding a reliable biomarker for the early detection of schizophrenia
(Scz) has been a topic of interest. The main goal of the current review is to provide a …