Chronic stress and the accompanying long-term elevation of glucocorticoids (GCs), the
stress hormones of the body, increase the risk and accelerate the progression of Alzheimer's …

Neurons are particularly vulnerable to mitochondrial dysfunction due to high energy demand
and an inability to proliferate. Therefore, dysfunctional mitochondria cause various …

The multifactorial origin and neurochemistry of Alzheimer's disease (AD) call for the
development of multitarget treatment strategies. We report a first-in-class triple acting …

Objective Although epilepsies and neurodegenerative disorders show pathophysiological
similarities, their direct functional associations are unclear. Here, we tested the hypothesis …

Alzheimer's disease (AD) is a brain disease with a peculiarity of multiformity and an
insidious onset. Multiple-target drugs, especially Chinese traditional medicine, have …

Microglial activation and neuroinflammation induced by amyloid β (Aβ) play pivotal roles in
Alzheimer's disease (AD) pathogenesis. Astragaloside IV (AS-IV) is one of the major active …

One of the biggest challenges in drug development for Alzheimer's disease (AD) is how to
effectively remove deposits of amyloid-beta (Aβ). Recently, the relationship between …

Alzheimer's disease (AD) is the most common form of dementia in the elderly, currently
affecting more than 40 million people worldwide. The two main histopathological hallmarks …

Abstract Ethnopharmacological relevance In traditional Chinese medicine, Shen Nong,
BenCao Jing, and Compendium of Materia Medica (Bencao Gangmu), Panax ginseng, and …

Glucocorticoids are powerful modulators of brain function. They act via mineralocorticoid
and glucocorticoid receptors (MR and GR). These are best understood as transcription …