This review aims to illustrate the importance of selenium (Se) for maintenance of overall
health, especially for the thyroid, immunity, and homeostasis. Furthermore, it outlines the …

The trace element selenium is an essential micronutrient that is required for the biosynthesis
of selenocysteine-containing selenoproteins. Most of the known selenoproteins are …

Oxidation of the catalytic cysteine of protein–tyrosine phosphatases (PTP), which leads to
their reversible inactivation, has emerged as an important regulatory mechanism linking …

Inheritance of a coding variant of the protein tyrosine phosphatase nonreceptor type 22
(PTPN22) gene is associated with increased susceptibility to autoimmunity and infection …

The PTPN22 locus is one of the strongest risk factors outside of the major histocompatability
complex that associates with autoimmune diseases. PTPN22 encodes lymphoid protein …

Reactive oxygen species (ROS) are a heterogeneous group of highly reactive molecules
that oxidize targets in a biologic system. During steady-state conditions, ROS are constantly …

The current review on the function of neutrophil cytosolic factor 1 (NCF1) and induced
reactive oxygen species (ROS) is based on a genetic search for the major genes controlling …

As key enzymes in the regulation of biological phosphorylations, protein-tyrosine
phosphatases are central to the control of cellular signaling and metabolism. Zinc (II) ions …

Protein tyrosine phosphatases (PTPs) are important targets of the H2O2 that is produced
during mammalian signal transduction. H2O2-mediated inactivation of PTPs also may be …

Normal cellular physiology is critically dependent on numerous mitochondrial activities
including energy conversion, cofactor and precursor metabolite synthesis, and regulation of …