Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Centrioles are microtubule-based core components of centrosomes and cilia. They are
duplicated exactly once during S-phase progression. Central to formation of each new …

Stimulated emission depletion (STED) microscopy is routinely used to resolve the
ultrastructure of cells with a∼ 10-fold higher resolution compared to diffraction limited …

Autosomal recessive primary microcephaly (MCPH;“small head syndrome”) is a rare,
heterogeneous disease arising from the decreased production of neurons during brain …

The self-assembly of protein complexes is at the core of many fundamental biological
processes, ranging from the polymerization of cytoskeletal elements, such as microtubules …

The centriole is a multifunctional structure that organizes centrosomes and cilia and is
important for cell signaling, cell cycle progression, polarity, and motility. Defects in centriole …

Tight control of centriole duplication is critical for normal chromosome segregation and the
maintenance of genomic stability. Polo-like kinase 4 (Plk4) is a key regulator of centriole …

The centriole is a beautiful microtubule-based organelle that is critical for the proper
execution of many fundamental cellular processes, including polarity, motility, and division …

Lysine acetylation is a widespread post-translational modification regulating various
biological processes. To characterize cellular functions of the human lysine …

Centrioles are essential for the formation of centrosomes and cilia. While numerical and/or
structural centrosomes aberrations are implicated in cancer, mutations in centriolar and …