Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023 - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology, and treatment

C Iadecola, RF Gottesman - Circulation research, 2019 - Am Heart Assoc
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

Impact of hypertension on cognitive function: a scientific statement from the American Heart Association

C Iadecola, K Yaffe, J Biller, LC Bratzke, FM Faraci… - …, 2016 - Am Heart Assoc
Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

What are white matter hyperintensities made of? Relevance to vascular cognitive impairment

JM Wardlaw, MC Valdés Hernández… - Journal of the …, 2015 - Am Heart Assoc
White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

Update on cerebral small vessel disease: a dynamic whole-brain disease

Y Shi, JM Wardlaw - Stroke and vascular neurology, 2016 - svn.bmj.com
Cerebral small vessel disease (CSVD) is a very common neurological disease in older
people. It causes stroke and dementia, mood disturbance and gait problems. Since it is …

Prevention of stroke in patients with silent cerebrovascular disease: a scientific statement for healthcare professionals from the American Heart Association/American …

EE Smith, G Saposnik, GJ Biessels, FN Doubal… - Stroke, 2017 - Am Heart Assoc
Two decades of epidemiological research shows that silent cerebrovascular disease is
common and is associated with future risk for stroke and dementia. It is the most common …

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

JM Wardlaw, C Smith, M Dichgans - The Lancet Neurology, 2013 - thelancet.com
The term cerebral small vessel disease (SVD) describes a range of neuroimaging,
pathological, and associated clinical features. Clinical features range from none, to discrete …

White matter hyperintensities and imaging patterns of brain ageing in the general population

M Habes, G Erus, JB Toledo, T Zhang, N Bryan… - Brain, 2016 - academic.oup.com
White matter hyperintensities are associated with increased risk of dementia and cognitive
decline. The current study investigates the relationship between white matter …

The vascular depression hypothesis: mechanisms linking vascular disease with depression

WD Taylor, HJ Aizenstein, GS Alexopoulos - Molecular psychiatry, 2013 - nature.com
Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …

The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis

S Debette, HS Markus - Bmj, 2010 - bmj.com
Objectives To review the evidence for an association of white matter hyperintensities with
risk of stroke, cognitive decline, dementia, and death. Design Systematic review and meta …