There is a compelling demand for approved plague vaccines due to the endemicity of
Yersinia pestis and its potential for pandemic spread. Whilst substantial progress has been …

Plague is one of the world's most lethal human diseases caused by Yersinia pestis, a Gram-
negative bacterium. Despite overwhelming studies for many years worldwide, there is no …

Genome-wide association studies (GWASs) have identified hundreds of loci harboring
genetic variation influencing inflammatory-disease susceptibility in humans. It has been …

Bacteria express different types of hair-like proteinaceous appendages on their cell surface
known as pili or fimbriae. These filamentous structures are primarily involved in the …

Symptomatic infection by Neisseria gonorrhoeae (Gc) produces a potent inflammatory
response, resulting in a neutrophil‐rich exudate. A population of Gc can survive the killing …

The genus Yersinia contains three species pathogenic for humans, one of which is the
enteropathogen Yersinia pseudotuberculosis. A recent analysis by Multi Locus Sequence …

In recent decades, the issue of emerging and re-emerging infectious diseases has become
an increasingly important area of concern in public health. Today, like centuries ago …

The etiologic agent of plague, Yersinia pestis, is a globally distributed pathogen which
poses both a natural and adversarial threat. Due largely to the rapid course and high …

Plague caused by Yersinia pestis is one of the most dangerous infectious diseases. There is
no ideal plague vaccine available for human use, but a number of licensed killed whole-cell …

Relatively recent advances in plague vaccinology have produced the recombinant fusion
protein F1-V plague vaccine. This vaccine has been shown to readily protect mice from both …