MicroRNA–mRNA networks in pregnancy complications: A comprehensive downstream analysis of potential biomarkers

A Ali, F Hadlich, MW Abbas, MA Iqbal… - International journal of …, 2021 - mdpi.com
Pregnancy complications are a major cause of fetal and maternal morbidity and mortality in
humans. The majority of pregnancy complications initiate due to abnormal placental …

Non-coding RNAs in preeclampsia—molecular mechanisms and diagnostic potential

J Munjas, M Sopić, A Stefanović, R Košir… - International Journal of …, 2021 - mdpi.com
Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality
worldwide. Defects in trophoblast invasion, differentiation of extravillous trophoblasts and …

[HTML][HTML] Discovery and verification of extracellular miRNA biomarkers for non-invasive prediction of pre-eclampsia in asymptomatic women

S Srinivasan, R Treacy, T Herrero, R Olsen… - Cell Reports …, 2020 - cell.com
Development of effective prevention and treatment strategies for pre-eclampsia is limited by
the lack of accurate methods for identification of at-risk pregnancies. We performed small …

Circulating miRNAs and preeclampsia: from implantation to epigenetics

SR Giannubilo, M Cecati, D Marzioni… - International Journal of …, 2024 - mdpi.com
In this review, we comprehensively present the literature on circulating microRNAs
(miRNAs) associated with preeclampsia, a pregnancy-specific disease considered the …

Discovery and verification of extracellular microRNA biomarkers for diagnostic and prognostic assessment of preeclampsia at triage

R Morey, L Poling, S Srinivasan, C Martinez-King… - Science …, 2023 - science.org
We report on the identification of extracellular miRNA (ex-miRNA) biomarkers for early
diagnosis and prognosis of preeclampsia (PE). Small RNA sequencing of maternal serum …

[HTML][HTML] miR-21-5p inhibits inflammation injuries in LPS-treated H9c2 cells by regulating PDCD4

J Xue, J Liu, B Xu, J Yu, A Zhang, L Qin… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Objectives: To explore the expression levels and the potential regulatory mechanism of miR-
21-5p in LPS-treated H9c2 cells. Methods: The secretions of the inflammatory cytokines …

Exosomes and exosomal non‑coding RNAs throughout human gestation

I Maligianni, C Yapijakis, K Nousia… - Experimental and …, 2022 - spandidos-publications.com
In recent years, research on exosomes and their content has been intensive, which has
revealed their important role in cell‑to‑cell communication, and has implicated exosomal …

Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation

AM Tseng, AH Mahnke, AB Wells… - Life science …, 2019 - life-science-alliance.org
Prenatal alcohol exposure (PAE), like other pregnancy complications, can result in placental
insufficiency and fetal growth restriction, although the linking causal mechanisms are …

Preeclamptic women have disrupted placental microRNA expression at the time of preeclampsia diagnosis: meta-analysis

A Cirkovic, D Stanisavljevic, J Milin-Lazovic… - … in Bioengineering and …, 2021 - frontiersin.org
Introduction: Preeclampsia (PE) is a pregnancy-associated, multi-organ, life-threatening
disease that appears after the 20th week of gestation. The aim of this study was to perform a …

Analysis of circulating microRNA signatures and preeclampsia development

ML Martinez-Fierro, I Garza-Veloz - Cells, 2021 - mdpi.com
microRNAs are important regulators of cell processes and have been proposed as potential
preeclampsia biomarkers. We evaluated serum microRNA expression profiling to identify …