Simple Summary Out of the billions of nucleotides comprising the human DNA, a substantial
proportion (98%) represents non-coding DNA, meaning DNA that is not translated into …

The function of a protein is strongly dependent on its structure. During evolution, proteins
acquire new functions through mutations in the amino-acid sequence. Given the advance in …

Renal carcinomas are a group of malignant tumors often originating in the cells lining the
small tubes in the kidney responsible for filtering waste from the blood and urine production …

Multi-omic approaches are expected to deliver a broader molecular view of cancer.
However, the promised mechanistic explanations have not quite settled yet. Here, we …

Gene co-expression networks have become a usual approach to integrate the vast amounts
of information coming from gene expression studies in cancer cohorts. The reprogramming …

Breast cancer is characterized as being a heterogeneous pathology with a broad phenotype
variability. Breast cancer subtypes have been developed in order to capture some of this …

Gene regulatory and signaling phenomena are known to be relevant players underlying the
establishment of cellular phenotypes. It is also known that such regulatory programs are …

Breast cancer is a heterogeneous disease comprising various subtypes with distinct
molecular characteristics, clinical outcomes, and therapeutic responses. This heterogeneity …

Hematopoietic cancers (HCs) are a heterogeneous group of malignancies that affect blood,
bone marrow and lymphatic system. Here, by analyzing 1960 RNA-Seq samples from three …

Gene co-expression networks are a useful tool in the study of interactions that have allowed
the visualization and quantification of diverse phenomena, including the loss of co …