Hox genes, a highly conserved subgroup of the homeobox superfamily, have crucial roles in
development, regulating numerous processes including apoptosis, receptor signalling …

Homeobox (HOX) transcription factors, encoded by a subset of homeodomain superfamily
genes, play pivotal roles in many aspects of cellular physiology, embryonic development …

Neuroblastoma is an embryonal malignancy of the sympathetic nervous system.
Spontaneous regression and differentiation of neuroblastoma is observed in a subset of …

Background Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex
involved in both the electron transport chain and the citric acid cycle. SDH mutations …

Mechanisms underlying pathological angiogenesis in relation to hypoxia in tumor invasion
and metastasis remain elusive. Here, we have developed a zebrafish tumor model that …

HOXB13 is a member of the homeodomain family of sequence-specific transcription factors
and, together with the androgen receptor (AR), plays a critical role in the normal …

Background Cancers have long been recognized to be not only genetically but also
epigenetically distinct from their tissues of origin. Although genetic alterations underlying …

Bivalent (poised or paused) chromatin comprises activating and repressing histone
modifications at the same location. This combination of epigenetic marks at promoter or …

ABSTRACT Yin Yang 1 (YY1) is a transcription factor with diverse and complex biological
functions. YY1 either activates or represses gene transcription, depending on the stimuli …

Hox genes code for transcription factors and are evolutionarily conserved. They regulate a
plethora of downstream targets to define the anterior-posterior (AP) body axis of a …