High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Modulation of human multipotent and pluripotent stem cells using surface nanotopographies and surface-immobilised bioactive signals: A review

PY Wang, H Thissen, P Kingshott - Acta biomaterialia, 2016 - Elsevier
The ability to control the interactions of stem cells with synthetic surfaces is proving to be
effective and essential for the quality of passaged stem cells and ultimately the success of …

Pore size effect of collagen scaffolds on cartilage regeneration

Q Zhang, H Lu, N Kawazoe, G Chen - Acta biomaterialia, 2014 - Elsevier
Scaffold pore size is an important factor affecting tissue regeneration efficiency. The effect of
pore size on cartilage tissue regeneration was compared by using four types of collagen …

Osteogenic differentiation of human mesenchymal stem cells in the absence of osteogenic supplements: A surface-roughness gradient study

AB Faia-Torres, M Charnley, T Goren… - Acta biomaterialia, 2015 - Elsevier
The use of biomaterials to direct osteogenic differentiation of human mesenchymal stem
cells (hMSCs) in the absence of osteogenic supplements is thought to be part of the next …

Arginine-presenting peptide hydrogels decorated with hydroxyapatite as biomimetic scaffolds for bone regeneration

M Ghosh, M Halperin-Sternfeld, I Grigoriants… - …, 2017 - ACS Publications
Hydrogels are promising candidates for biomimetic scaffolds of the extracellular matrix in
tissue engineering applications. However, their use in bone tissue engineering is limited …

Converting 2D nanofiber membranes to 3D hierarchical assemblies with structural and compositional gradients regulates cell behavior

S Chen, A McCarthy, JV John, Y Su… - Advanced Materials, 2020 - Wiley Online Library
New methods are described for converting 2D electrospun nanofiber membranes to 3D
hierarchical assemblies with structural and compositional gradients. Pore‐size gradients are …

Molecular co-assembly as a strategy for synergistic improvement of the mechanical properties of hydrogels

M Halperin-Sternfeld, M Ghosh… - Chemical …, 2017 - pubs.rsc.org
Molecular self-assembly is a key direction for the fabrication of advanced materials. Yet, the
physical properties of the formed assemblies are limited by the inherent characteristics of the …

Time-responsive osteogenic niche of stem cells: a sequentially triggered, dual-peptide loaded, alginate hybrid system for promoting cell activity and osteo …

Z Luo, S Zhang, J Pan, R Shi, H Liu, Y Lyu, X Han, Y Li… - Biomaterials, 2018 - Elsevier
The efficacy of stem cell-based bone tissue engineering has been hampered by cell death
and limited fate control. A smart cell culture system with the capability of sequentially …

Modulation of human mesenchymal and pluripotent stem cell behavior using biophysical and biochemical cues: A review

S Ding, P Kingshott, H Thissen, M Pera… - Biotechnology and …, 2017 - Wiley Online Library
In vitro manipulation of human stem cells is a critical process in regenerative medicine and
cellular therapies. Strategies and methods to maintain stem cells and direct them into …

The bumpy road to stem cell therapies: Rational design of surface topographies to dictate stem cell mechanotransduction and fate

J Carthew, JBJ Taylor, MR Garcia-Cruz… - … Applied Materials & …, 2022 - ACS Publications
Cells sense and respond to a variety of physical cues from their surrounding
microenvironment, and these are interpreted through mechanotransductive processes to …