Over the last decade, single-cell genomics has revealed remarkable heterogeneity and
plasticity of cell types in the lungs and airways. The challenge now is to understand how …

Spatial transcriptomics (ST) is a newly emerging field that integrates high-resolution imaging
and transcriptomic data to enable the high-throughput analysis of the spatial localization of …

The growth of omic data presents evolving challenges in data manipulation, analysis and
integration. Addressing these challenges, Bioconductor provides an extensive community …

Abstract Summary Visium HD by 10X Genomics is the first commercially available platform
capable of capturing full scale transcriptomic data paired with a reference morphology …

Uveal melanoma (UM) is a highly aggressive and fatal tumor in the eye, and due the special
biology of UM, immunotherapy showed little effect in UM patients. To improve the efficacy of …

Ovarian cancer (OC) represents ecosystems of highly diverse tumor microenvironments
(TMEs). The presence of tumor-infiltrating lymphocytes (TILs) is linked to enhanced immune …

Immune checkpoint inhibitor (ICI) therapy has revolutionized renal cell carcinoma treatment.
Patients previously thought to be palliative now occasionally achieve complete cures from …

Improvement of long-term outcomes through targeted treatment is a primary concern in
kidney transplant medicine. Currently, the validation of a rejection diagnosis and …

During development, cell signaling instructs tissue patterning, the process by which initially
identical cells give rise to spatially organized structures consisting of different cell types …

Gastric cancer (GC) is a prominent contributor to global cancer‑related mortalities, and a
deeper understanding of its molecular characteristics and tumor heterogeneity is required …