Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

In 1975, tau protein was isolated as a microtubule-associated factor from the porcine brain.
In the previous year, a paired helical filament (PHF) protein had been identified in …

Microtubule associated protein tau is a phosphoprotein which potentially has 80
serine/threonine and 5 tyrosine phosphorylation sites. Normal brain tau contains 2-3 moles …

As our global population ages, the treatment of neurodegenerative diseases is critical to our
society. In recent years, researchers have begun to study the role of biologically active …

Traumatic brain injury is a common and serious neurodegenerative condition that lacks a
pharmaceutical intervention to improve long-term outcome. Hyperphosphorylated tau is …

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase originally identified as a
regulator of glycogen metabolism but it also plays a pivotal role in numerous cellular …

There are no treatments in clinical practice known to mitigate the neurobiological processes
that convert a healthy brain into an epileptic one, a phenomenon known as epileptogenesis …

Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of
neurodegenerative disorders, the most common of which is Alzheimer's disease. While they …

Alzheimer's disease (AD) is an incurable and debilitating chronic progressive
neurodegenerative disorder which is the leading cause of dementia worldwide. AD is a …

Abstract Alzheimer's disease (AD), one of the leading neurodegenerative disorders of older
adults, which causes major socioeconomic burdens globally, lacks effective therapeutics …