Membranes are fundamental elements within organ-on-a-chip (OOC) platforms, as they
provide adherent cells with support, allow nutrients (and other relevant molecules) to …

The approval of anticancer therapeutic strategies is still slowed down by the lack of models
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …

The use of microfluidic devices in biomedicine is growing rapidly in applications such as
organs-on-chip and separations. Polydimethylsiloxane (PDMS) is the most popular material …

Organotypic and microphysiological systems (MPS) that can emulate the molecular
phenotype and function of human tissues, such as liver, are increasingly used in preclinical …

Determining the potential cardiotoxicity and pro-arrhythmic effects of drug candidates
remains one of the most relevant issues in the drug development pipeline (DDP). New …

Microfluidic chips are valuable tools for studying intricate cellular and cell–microenvironment
interactions. Traditional in vitro cancer models lack accuracy in mimicking the complexities …

Polydimethylsiloxane (PDMS) has been widely used to make lab-on-a-chip devices, such as
reactors and sensors, for biological research. Real-time nucleic acid testing is one of the …

Blood coagulation is a highly regulated injury response that features polymerization of fibrin
fibers to prevent the passage of blood from a damaged vascular endothelium. A growing …

Background Functional drug testing (FDT) with patient-derived tumor cells in microfluidic
devices is gaining popularity. However, the majority of previously reported microfluidic …

The limitations of conventional animal tests and two-dimensional cell culture hinder their
advancement in fundamental research and clinical/translational applications. As an …