Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

The tripeptide glutathione is found in all eukaryotic cells, and due to the
compartmentalization of biochemical processes, its synthesis takes place exclusively in the …

Cancer is characterized by increased oxidative stress, an imbalance between reactive
oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of …

H 2 O 2 signals trigger adaptive responses affecting cell division, differentiation, migration,
and survival. These signals are transduced by selective oxidation of cysteines on specific …

Abstract Peroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as H 2 O 2
detoxifiers, and more recently as H 2 O 2 sensors, intermediates in redox-signaling …

Tumour cells often display an active metabolic profile, leading to the intracellular
accumulation of reactive oxygen species. As a member of the peroxidase family …

Biological milieus are highly crowded and heterogeneous systems where organization of
macromolecules within nanodomains (eg membraneless compartments) is vital to the …

Nonalcoholic fatty liver disease (NAFLD), characterized by ectopic fat accumulation in
hepatocytes, is closely linked to insulin resistance and is the most frequent complication of …

Oxygen is the sustenance of aerobic life and yet is highly toxic. In early life, antioxidants
functioned solely to defend against toxic effects of reactive oxygen species (ROS). Later, as …

The concept of oxidative distress had arisen from the assessment of cellular response to
high concentrations of reactive species that result from an imbalance between oxidants and …