Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …

Although amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, was first
described in 1874, a flurry of genetic discoveries in the last 10 years has markedly increased …

Astrocytes are thought to have important roles after brain injury, but their behavior has
largely been inferred from postmortem analysis. To examine the mechanisms that recruit …

Activation of microglia, CNS resident immune cells, is a pathological hallmark of
amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting motor neurons …

Background Non-cell autonomous toxicity is one of the potential mechanisms implicated in
the etiopathogenesis of amyotrophic lateral sclerosis (ALS). However, the exact role of glial …

Astrocytes are key cells for adequate brain formation and regulation of cerebral blood flow
as well as for the maintenance of neuronal metabolism, neurotransmitter synthesis and …

In vivo optical imaging has enabled detailed studies of cellular dynamics in the brain of
rodents in both healthy and diseased states. Such studies were made possible by three …

Mutations in SOD1 cause hereditary variants of the fatal motor neuron disease amyotrophic
lateral sclerosis (ALS). Pathophysiology of the disease is non-cell-autonomous, with toxicity …

Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that
primarily affects motor neurons in the brain and spinal cord. Histone deacetylase (HDAC) …

Background Glioblastoma multiforme is the most aggressive brain tumor. Microglia are
prominent cells within glioma tissue and play important roles in tumor biology. This work …