The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

The blood-brain barrier (BBB) is a physical and biochemical barrier that precisely controls
cerebral homeostasis. It also plays a central role in the regulation of blood-to-brain flux of …

Intravenous thrombolysis via tPA (tissue-type plasminogen activator) is the only approved
pharmacological treatment for acute ischemic stroke, but its benefits are limited by …

Clinical treatments for ischemic stroke are limited. Neural stem cell (NSC) transplantation
can be a promising therapy. Clinically, ischemia and subsequent reperfusion lead to …

Ischemic stroke starts a series of pathophysiological processes that cause brain injury.
Caveolin-1 (cav-1) is an integrated protein and locates at the caveolar membrane. It has …

Introduction Clinically, significant stroke injury results from ischemia-reperfusion (IR), which
induces a deleterious biphasic opening of the blood-brain barrier (BBB). Tissue …

The astrocyte-endothelial cell interaction is crucial for normal brain homeostasis and blood-
brain barrier (BBB) disruption in pathological conditions. However, the mechanism by which …

The mechanisms of secondary brain injury after traumatic brain injury (TBI) are complex and
are the result of multiple factors. Protecting the blood-brain barrier (BBB) and ameliorating …

Disruption of the blood brain barrier (BBB) within the thrombolytic time window is an
antecedent event to intracerebral hemorrhage in ischemic stroke. Our recent studies showed …

Increased blood-brain barrier (BBB) permeability can lead to cerebral vasogenic edema and
hemorrhagic transformation (HT) after reperfusion with tissue plasminogen activator (tPA) …