Early-Onset Colorectal Cancer Early-onset disease (at< 50 years of age) accounts for 10%
of colorectal cancer cases, and the incidence is increasing, particularly in high-income …

Mortality from colorectal cancer is reduced through screening and early detection; moreover,
removal of neoplastic lesions can reduce cancer incidence. While understanding of the risk …

Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Although
most prevalent among older people, its incidence above 50 years old has been decreasing …

Importance Hereditary factors play a key role in the risk of developing several cancers.
Identification of a germline predisposition can have important implications for treatment …

Computational pathology uses artificial intelligence to enable precision medicine and
decision support systems through the analysis of whole slide images. It has the potential to …

In contrast to the decreasing incidence of colorectal cancer (CRC) in older populations, the
incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in …

Background The causative factors for the recent increase in early-onset colorectal cancer
(EO-CRC) incidence are unknown. We sought to determine if early-onset disease is …

Colorectal cancer (CRC) incidence rates in the United States overall have declined since
the mid-1980s because of changing patterns in risk factors (eg, decreased smoking) and …

Background Existing clinical practice guidelines for carriers of pathogenic variants of DNA
mismatch repair genes (Lynch syndrome) are based on the mean age-specific cumulative …

Cancer is a leading cause of death in the United States and across the globe. Cancer
screening is an effective preventive measure that can reduce cancer incidence and …