From genome-wide associations to candidate causal variants by statistical fine-mapping
Advancing from statistical associations of complex traits with genetic markers to
understanding the functional genetic variants that influence traits is often a complex process …
understanding the functional genetic variants that influence traits is often a complex process …
Prostate carcinogenesis: inflammatory storms
Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic
inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an …
inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an …
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations
remain limited due to an imbalance in genetic studies across ancestrally diverse …
remain limited due to an imbalance in genetic studies across ancestrally diverse …
A large-scale genome-wide association study in US Holstein cattle
Genome-wide association study (GWAS) is a powerful approach to identify genomic regions
and genetic variants associated with phenotypes. However, only limited mutual confirmation …
and genetic variants associated with phenotypes. However, only limited mutual confirmation …
Evidence of novel susceptibility variants for prostate cancer and a multiancestry polygenic risk score associated with aggressive disease in men of African ancestry
Background Genetic factors play an important role in prostate cancer (PCa) susceptibility.
Objective To discover common genetic variants contributing to the risk of PCa in men of …
Objective To discover common genetic variants contributing to the risk of PCa in men of …
Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers
Transcriptome-wide association studies (TWAS) have successfully discovered many
putative disease susceptibility genes. However, TWAS may suffer from inaccuracy of gene …
putative disease susceptibility genes. However, TWAS may suffer from inaccuracy of gene …
Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects
Prostate cancer (PrCa) is the second most common cancer worldwide in males. While
strongly warranted, the prediction of mortality risk due to PrCa, especially before its …
strongly warranted, the prediction of mortality risk due to PrCa, especially before its …
Post-GWAS in prostate cancer: from genetic association to biological contribution
Genome-wide association studies (GWAS) have been successful in deciphering the genetic
component of predisposition to many human complex diseases including prostate cancer …
component of predisposition to many human complex diseases including prostate cancer …
Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms
While many germline cancer risk variants have been identified through genome-wide
association studies (GWAS), the mechanisms by which these variants operate remain …
association studies (GWAS), the mechanisms by which these variants operate remain …