In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

BACKGROUND The core of the mammalian circadian clock mechanism is a time-delayed
transcription-translation feedback loop (TTFL), which influences the transcription and …

Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …

Physicians diagnose and administer treatment as needed; time of day is rarely considered.
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …

Timing chemotherapy on the basis of the body's intrinsic circadian clock—ie,
chronomodulated chemotherapy—might improve efficacy and reduce treatment toxicity. This …

The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological
and behavioral functions of almost all species. This pattern is due to a fundamental …

Virtually every eukaryotic cell has an endogenous circadian clock and a biological sex.
These cell-based clocks have been conceptualized as oscillators whose phase can be reset …