Targeting RNA structures with small molecules
JL Childs-Disney, X Yang, QMR Gibaut… - Nature Reviews Drug …, 2022 - nature.com
RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …
dysfunction in disease. Approaches to therapeutically target RNA structures with small …
RNA contributions to the form and function of biomolecular condensates
C Roden, AS Gladfelter - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Biomolecular condensation partitions cellular contents and has important roles in stress
responses, maintaining homeostasis, development and disease. Many nuclear and …
responses, maintaining homeostasis, development and disease. Many nuclear and …
Rapid, ultrasensitive, and quantitative detection of SARS-CoV-2 using antisense oligonucleotides directed electrochemical biosensor chip
A large-scale diagnosis of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-
2) is essential to downregulate its spread within as well as across communities and mitigate …
2) is essential to downregulate its spread within as well as across communities and mitigate …
Selective naked-eye detection of SARS-CoV-2 mediated by N gene targeted antisense oligonucleotide capped plasmonic nanoparticles
The current outbreak of the pandemic coronavirus disease 2019 (COVID-19) caused by the
severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) demands its rapid …
severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) demands its rapid …
The roles of structural dynamics in the cellular functions of RNAs
RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
Analyzing miRNA–lncRNA interactions
MD Paraskevopoulou, AG Hatzigeorgiou - Long non-coding RNAs …, 2016 - Springer
Long noncoding RNAs (lncRNAs) are noncoding transcripts usually longer than 200 nts that
have recently emerged as one of the largest and significantly diverse RNA families. The …
have recently emerged as one of the largest and significantly diverse RNA families. The …
RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19
The global pandemic of coronavirus disease 2019 (COVID-19) highlights the shortcomings
of the current testing paradigm for viral disease diagnostics. Here, we report a stepwise …
of the current testing paradigm for viral disease diagnostics. Here, we report a stepwise …
Advancement of the emerging field of RNA nanotechnology
The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of
programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …
programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …
[HTML][HTML] The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse
The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the
activation state of genes controlling pluripotency, lineage commitment, and cell …
activation state of genes controlling pluripotency, lineage commitment, and cell …
MicroRNAs in development and disease
D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …
introduced an additional level of intricacy to our understanding of gene regulation. There are …