The immunosuppressive tumor microenvironment represents not only one of the key factors
stimulating tumor progression but also a strong obstacle for efficient tumor immunotherapy …

Tumor progression has been demonstrated to be supported by chronic inflammatory
conditions developed in the tumor microenvironment and characterized by the long-term …

The NOD-like receptor 3 (NLRP3) inflammasome-mediated inflammation is recently
recognized in the development of renal injury. However, the mechanisms of the …

Inflammasomes are intracellular multiprotein complexes in the cytoplasm that regulate
inflammation activation in the innate immune system in response to pathogens and to host …

Tumor progression is often associated with chronic inflammation in the tumor
microenvironment, which is mediated by numerous cytokines, chemokines and growth …

Study design: Randomized experimental study. Objectives: To investigate the molecular
mechanisms of quercetin in spinal cord injury (SCI) rats. Setting: China. Methods: One …

Targeting posttraumatic inflammation is crucial for improving locomotor function. SIRT1 has
been shown to play a critical role in disease processes such as hepatic inflammation …

Aims The present study investigated the therapeutic efficacy of asiatic acid (AA) on spinal
cord injury (SCI) as well as the underlying mechanisms. Main methods Sprague-Dawley rats …

Study Design. A randomized experimental study. Objective. The aim of this study was to
investigate the therapeutic efficacy and molecular mechanisms of dopamine D1 receptor …

Background Neuroinflammatory responses involve the activation of the interleukin (IL)-1β
and IL-18. Processing and activation of the pro-inflammatory IL require NLRP3 …