Microglial cells, which are highly plastic, immediately respond to any change in the
microenvironment by becoming activated and shifting the phenotype toward neurotoxicity or …

Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide,
and they can lead to severely damaging consequences such as permanent disability and …

Tissue repair after spinal cord injury requires the mobilization of immune and glial cells to
form a protective barrier that seals the wound and facilitates debris clearing, inflammatory …

Abstract Histone deacetylase 3 (HDAC3) is an epigenetic regulator that involves gene
expression, apoptosis, and cell cycle progression, and the overexpression of HDAC3 is …

Disease, injury and aging induce pathological reactive astrocyte states that contribute to
neurodegeneration. Modulating reactive astrocytes therefore represent an attractive …

Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …

HDAC3 is a specific and crucial member of the HDAC family. It is required for embryonic
growth, development, and physiological function. The regulation of oxidative stress is an …

The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …

The innate immune response influences neural repair after spinal cord injury (SCI). Here, we
combined myeloid-specific transcriptomics and single-cell RNA sequencing to uncover not …

Abstract Background Histone deacetylases (HDACs) are believed to exacerbate traumatic
brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform …