[HTML][HTML] The role of nuclear receptors in the pathogenesis and treatment of non-alcoholic fatty liver disease
Z Yang, A Danzeng, Q Liu, C Zeng, L Xu… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is a global health burden closely linked to insulin
resistance, obesity, and type 2 diabetes. The complex pathophysiology of NAFLD involves …
resistance, obesity, and type 2 diabetes. The complex pathophysiology of NAFLD involves …
B3galt5 functions as a PXR target gene and regulates obesity and insulin resistance by maintaining intestinal integrity
J Zhang, Y Huang, H Li, P Xu, Q Liu, Y Sun… - Nature …, 2024 - nature.com
Pregnane X receptor (PXR) has been reported to regulate glycolipid metabolism. The
dysfunction of intestinal barrier contributes to metabolic disorders. However, the role of …
dysfunction of intestinal barrier contributes to metabolic disorders. However, the role of …
Insights of Direct and Indirect Regulation of PXR through Phosphorylation in Fatty Liver Disease
The Pregnane X receptor, a ligand-activated nuclear receptor, regulates the transcription of
several genes that encode many enzymes and transporters related to drug metabolism. PXR …
several genes that encode many enzymes and transporters related to drug metabolism. PXR …
Copper oxide nanoparticles induce non-alcoholic fatty liver disease by disrupting bile acid homeostasis and perturbing the intestinal microbial homeostasis
M Jiang, X Tao, Y Pang, Z Qin, E Song… - Journal of Hazardous …, 2024 - Elsevier
The wide application of copper oxide nanoparticles (CuO NPs) in various fields such as
medicine, food, agriculture, and animal husbandry can result in direct or indirect oral …
medicine, food, agriculture, and animal husbandry can result in direct or indirect oral …
MAFLD as part of systemic metabolic dysregulation
J Zhao, L Liu, YY Cao, X Gao, G Targher… - Hepatology …, 2024 - Springer
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide. In recent years, a new terminology and definition of metabolic dysfunction …
worldwide. In recent years, a new terminology and definition of metabolic dysfunction …
The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity
B Attema, O Kummu, M Krutáková, P Pavek… - Archives of …, 2024 - Springer
Propiconazole is a triazole fungicide previously shown to induce triglyceride accumulation in
human liver HepaRG cells, potentially via activation of the Pregnane X Receptor (PXR) …
human liver HepaRG cells, potentially via activation of the Pregnane X Receptor (PXR) …