Intraflagellar transport (IFT) is a form of motor‐dependent cargo transport that is essential for
the assembly, maintenance, and length control of cilia, which play critical roles in motility …

Cilia and flagella are microtubule-based organelles whose assembly requires a motile
process, known as intraflagellar transport (IFT), to bring tubulin and other components to the …

Background Although the origin of the eukaryotic cell has long been recognized as the
single most profound change in cellular organization during the evolution of life on earth …

The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …

Distinct mutations in the centrosomal-cilia protein CEP290 lead to diverse clinical findings in
syndromic ciliopathies. We show that CEP290 localizes to the transition zone in ciliated …

As motile organelles and sensors, cilia play pivotal roles in cell physiology, development
and organ homeostasis. Ciliary defects are associated with a class of cilia-related diseases …

Sensory organelle cilia have critical roles in mammalian embryonic development and tissue
homeostasis. Intraflagellar transport (IFT) machinery is required for the assembly and …

The transition zone (TZ) of eukaryotic cilia and flagella is a structural intermediate between
the basal body and the axoneme that regulates ciliary traffic. Mutations in genes encoding …

Once thought of as a vestigial organelle, the primary cilium is now recognized as a signaling
hub for key cellular pathways in vertebrate development. The recent renaissance in cilia …

The primary cilium compartmentalizes a tiny fraction of the cell surface and volume, yet
many proteins are highly enriched in this area and so efficient mechanisms are necessary to …