Cancer is a disease of the genome caused by oncogene activation and tumor suppressor
gene inhibition. Deep sequencing studies including large consortia such as TCGA and …

Current evidence strongly suggests that aberrant activation of the NF-κB signalling pathway
is associated with carcinogenesis. A number of key cellular processes are governed by the …

Hepatocellular carcinoma (HCC) develops on the background of chronic hepatitis.
Leukocytes found within the HCC microenvironment are implicated as regulators of tumour …

Nasopharyngeal carcinoma (NPC) is a unique EBV‐associated subtype of head and neck
cancer, which has the highest incidence in Southern China and eastern South Asia. The …

The complex interplay of epigenetic factors is essential in regulating the hallmarks of cancer
and orchestrating intricate molecular interactions during tumor progression. Circular RNAs …

Inflammasomes play important roles in the pathogenesis of tumors, but the roles of NLRP3
inflammasome in the lymphoma remain unclear. Activated NLRP3 inflammasome induces …

Consistent experimental data suggest the importance of inflammation-associated oxidative
stress in colorectal cancer (CRC) pathogenesis. Inflammatory bowel disease with chronic …

Nuclear factor-kappa B1 (NF-κB1) is a pleiotropic transcription factor and key contributor to
tumorigenesis in many types of cancer. Numerous studies have addressed the association …

Colorectal cancer is a leading form of cancer in both males and females. Early detection of
individuals at risk of colorectal cancer allows proper treatment and management of the …

Background Meat and dietary fiber are associated with increased and decreased risk of
colorectal cancer (CRC), respectively. Toll-like receptors (TLRs) regulate the intestinal …