Role of chemokine systems in cancer and inflammatory diseases

H Li, M Wu, X Zhao - MedComm, 2022 - Wiley Online Library
Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

Advances in chemokine signaling pathways as therapeutic targets in glioblastoma

RM Urbantat, P Vajkoczy, S Brandenburg - Cancers, 2021 - mdpi.com
Simple Summary Chemokine signaling is crucial for tumorigenesis, proliferation,
angiogenesis, tumor progression and metastasis in glioblastoma. Furthermore, chemokines …

IL-8/CXCR1/2 signalling promotes tumor cell proliferation, invasion and vascular mimicry in glioblastoma

I Sharma, A Singh, F Siraj, S Saxena - Journal of biomedical science, 2018 - Springer
Background Glioblastoma multiforme (GBM) is one of the lethal malignant tumors of the
central nervous system. Despite advances made in understanding this complex disease …

The duality of CXCR3 in glioblastoma: unveiling autocrine and paracrine mechanisms for novel therapeutic approaches

TYH Chan, JSY Wong, KMY Kiang, CWY Sun… - Cell Death & …, 2023 - nature.com
Glioblastoma (GBM) is a highly aggressive brain tumor associated with limited therapeutic
options and a poor prognosis. CXCR3, a chemokine receptor, serves dual autocrine …

CCL2 activates AKT signaling to promote glycolysis and chemoresistance in glioma cells

Y Qian, P Ding, J Xu, X Nie, B Lu - Cell Biology International, 2022 - Wiley Online Library
The incidence of gliomas is increasing. Although great progress in glioma treatment has
been made, the clinical outcome remains unsatisfactory. Chemokine (C‐C motif) ligand 2 …

Chemokine signaling in tumors: potential role of CXC chemokines and their receptors as glioblastoma therapeutic targets

A Corsaro, B Tremonti, A Bajetto, F Barbieri… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Glioblastoma is the most aggressive brain tumor, typically associated with poor
prognosis. Its treatment is challenging due to the peculiar glioblastoma cell biology and its …

[HTML][HTML] Gene expression profiling of chemokines and their receptors in low and high grade astrocytoma

I Sharma, A Singh, KC Sharma… - Asian Pacific journal of …, 2017 - ncbi.nlm.nih.gov
Background: Despite intense interest in molecular characterization and searches for novel
therapeutic targets, the glioblastoma remains a formidable clinical challenge. Among many …

Novel therapeutics for brain tumors: Current practice and future prospects

N El Demerdash, J Kedda, N Ram… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction: Malignant gliomas are the most common and aggressive primary brain tumor
with current available therapies increasing median survival to a modest 20 months. Multiple …

CXCR3-Flavonoid Interaction: A Novel Therapeutic Approach in Cancer Immunotherapy

H Güngör, AD Demirag - Kocaeli Üniversitesi Sağlık Bilimleri Dergisi, 2024 - dergipark.org.tr
Objective: To investigate the interactions between select flavonoids (Luteolin, Quercetin,
Apigenin, Kaempferol, and Amorphine) and the CXCR3 receptor, evaluating their potential …

[HTML][HTML] Calycosin (CA) inhibits proliferation, migration and invasion by suppression of CXCL10 signaling pathway in glioma

X Zheng, D Chen, M Li, J Liao, L He, L Chen… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Glioblastoma is the most common malignant tumor in the central nervous system and its
occurrence and development is involved in various molecular abnormalities. CXC …