Venom phospholipase A2 (PLA2) enzymes share similarity in structure and catalytic function
with mammalian enzymes. However, in contrast to mammalian enzymes, many are toxic and …

The voltage-gated Na+, Ca*+, and K+ channels are responsible for the generation of action
potentials in neurons and other excitable cells. These channels are also involved in cellular …

Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain
is enhanced by the association of two different types of subunits, the membrane-bound, pore …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Dendrotoxins are small proteins that were isolated 20 years ago from mamba (Dendroaspis)
snake venoms (Harvey, AL, Karlsson, E., 1980. Dendrotoxin from the venom of the green …

The charybdotoxin receptor, purified from bovine tracheal smooth muscle, consists of two
subunits (alpha and beta) and, when reconstituted into planar lipid bilayers, forms functional …

Phospholipase A2 (PLA2) enzymes from snake venom are toxic and induce a wide
spectrum of pharmacological effects, despite similarity in primary, secondary and tertiary …

For many years, neuronal K'channels were pharmacological orphans, essential membrane
proteins against which'no natural toxins were known. While biochemically and …

Rat brain cDNA and genomic clones encoding three K+ channels, K, l, K, 2, and K, 3, have
been isolated by screening with Shaker probes and encode proteins of 602,530, and 525 …

The principal subunits of the voltage-gated Na÷, Ca z÷ and K÷ channels are members of a
related gene family and are functionally autonomous in voltage-dependent activation, ion …