Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Enzyme cascades are a powerful technology to develop environmentally friendly and cost-
effective synthetic processes to manufacture drugs, as they couple different …

Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing,
offering levels of selectivity and tunability that can dramatically improve chemical synthesis …

Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for
the treatment of COVID-19. Given the potential high demand and urgency for this compound …

Highlights•Multiple levels of metabolic engineering can be defined, from 'copy and paste'to
various forms of 'synthetic metabolism'.•The biochemical solution space for 'synthetic …

In vitro enzyme cascades possess great benefits, such as their synthetic capabilities for
complex molecules, no need for intermediate isolation, and the shift of unfavorable equilibria …

Natural products continue to play a pivotal role in drug-discovery efforts and in the
understanding of human health. The ability to extend nature's chemistry through …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

How individual enzymes evolved is relatively well understood. However, individual enzymes
rarely confer a physiological advantage on their own. Judging by its current state, the …

Synthetic biology is touted as the next industrial revolution as it promises access to greener
biocatalytic syntheses to replace many industrial organic chemistries. Here, it is shown to …