Approved nanomedicine against diseases

Y Jia, Y Jiang, Y He, W Zhang, J Zou, KT Magar… - Pharmaceutics, 2023 - mdpi.com
Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases.
Nanotechnology represents one of the most effective approaches in elevating a drug's …

Overview of recent advances in nano-based ocular drug delivery

LC Liu, YH Chen, DW Lu - International Journal of Molecular Sciences, 2023 - mdpi.com
Ocular diseases profoundly impact patients' vision and overall quality of life globally.
However, effective ocular drug delivery presents formidable challenges within clinical …

Layer-by-layer oral-deliverable nanoparticles targeted microfold cells to promote lutein absorption in alleviating dry eye disease

R Liu, S Fei, X Zhang, Z Hua, M Tan - Chemical Engineering Journal, 2024 - Elsevier
Bioactive compound intervention of dry eye disease has been considered as a promising
approach due to the lower adverse reactions. In this study, layer-by-layer oral-deliverable …

Membrane Fusion‐Mediated Loading of Therapeutic siRNA into Exosome for Tissue‐Specific Application

M Xie, Y Wu, Y Zhang, R Lu, Z Zhai, Y Huang… - Advanced …, 2024 - Wiley Online Library
Tissue‐specific delivery of oligonucleotide therapeutics beyond the liver remains a key
challenge in nucleic acid drug development. To address this issue, exploiting exosomes as …

Advances in Extracellular-Vesicles-Based Diagnostic and Therapeutic Approaches for Ocular Diseases

Y Su, M Chen, W Xu, P Gu, X Fan - ACS nano, 2024 - ACS Publications
Extracellular vesicles (EVs) are nanoscale membrane vesicles of various sizes that can be
secreted by most cells. EVs contain a diverse array of cargo, including RNAs, lipids …

Multifunctional Nanotherapeutics with Long-Acting Release against Macular Degeneration by Minimally Invasive Administration

W Chang, X Lv, J Zhu, JJ Shen, J Yao, Z Liu, Q Chen - ACS nano, 2024 - ACS Publications
Neovascular age-related macular degeneration (AMD), a leading cause of blindness,
requires frequent intravitreal injection of antivascular endothelial growth factor (anti-VEGF) …

Engineered assemblies from isomeric pentapeptides augment dry eye treatment

Y Zhang, T Zhou, Y Qi, Y Li, Y Zhang, Y Zhao… - Journal of Controlled …, 2024 - Elsevier
Changing positions of amino acid residues in the peptide sequence alters the peptide's
assembly behaviors, affording various nanostructures. However, it remains elusive that how …

Overcoming Treatment Challenges in Posterior Segment Diseases with Biodegradable Nano-Based Drug Delivery Systems

KY Wu, M Joly-Chevrier, D Akbar, SD Tran - Pharmaceutics, 2023 - mdpi.com
Posterior segment eye diseases present a challenge in treatment due to the complex
structures in the eye that serve as robust static and dynamic barriers, limiting the penetration …

Rosmarinic acid-grafted gelatin nanogels for efficient diquafosol delivery in dry eye disease therapy

T Zhou, S Li, J Zhu, G Zeng, Z Lv, M Zhang… - Journal of Controlled …, 2024 - Elsevier
Dry eye disease (DED) is a prevalent ocular disorder characterized by unstable tear film
condition with loss of aqueous or mucin, excessive oxidative stress, and inflammation …

[HTML][HTML] A review on dry eye disease treatment: recent Progress, diagnostics, and future perspectives

H Mondal, HJ Kim, N Mohanto, JP Jee - Pharmaceutics, 2023 - mdpi.com
Dry eye disease is a multifactorial disorder of the eye and tear film with potential damage to
the ocular surface. Various treatment approaches for this disorder aim to alleviate disease …