Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a
common feature of chronic tissue injury. Pulmonary fibrosis, renal fibrosis, and hepatic …

The stroma in solid tumors contains a variety of cellular phenotypes and signaling pathways
associated with wound healing, leading to the concept that a tumor behaves as a wound that …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and
biochemical features of smooth muscle (SM) cells, including the presence of microfilament …

The extracellular matrix (ECM) is a living network of proteins that maintains the structural
integrity of the myocardium and allows the transmission of electrical and mechanical forces …

The contraction of granulation tissue from skin wounds was first described in the 1960s.
Later it was discovered that during tissue repair, fibroblasts undergo a change in phenotype …

Reciprocal interactions between epithelium and mesenchyme mediate crucial aspects of
embryonic development and direct the coordinated organogenesis, correct spatial …

Myofibroblast differentiation and activation by transforming growth factor-ॆ1 (TGF-ॆ1) is a
critical event in the pathogenesis of human fibrotic diseases, but regulatory mechanisms for …

The aim of the present study was to elucidate how transforming growth factor-β1 (TGF-β1)
can stimulate collagen deposition in cardiac tissue by interstitial cells via stimulation of …

The role of transforming growth factor-β1 (TGF-β1) in the production and deposition of
collagens and in the induction of gene expression in the myocardium in relation to the …