[HTML][HTML] Allosteric communication and signal transduction in proteins
N Wu, M Barahona, SN Yaliraki - Current Opinion in Structural Biology, 2024 - Elsevier
Allostery is one of the cornerstones of biological function, as it plays a fundamental role in
regulating protein activity. The modelling of allostery has gradually moved from a …
regulating protein activity. The modelling of allostery has gradually moved from a …
Epigenetic modification and BRAF gene mutation in thyroid carcinoma
G Huang, J Chen, J Zhou, S Xiao, W Zeng, J Xia… - Cancer cell …, 2021 - Springer
Thyroid cancer remains the most prevailing endocrine malignancy, and a progressively
increasing incidence rate has been observed in recent years, with 95% of thyroid cancer …
increasing incidence rate has been observed in recent years, with 95% of thyroid cancer …
Identification of 5-nitroindazole as a multitargeted inhibitor for CDK and transferase kinase in lung cancer: a multisampling algorithm-based structural study
Lung cancer is the second most common cancer, which is the leading cause of cancer death
worldwide. The FDA has approved almost 100 drugs against lung cancer, but it is still not …
worldwide. The FDA has approved almost 100 drugs against lung cancer, but it is still not …
Multisampling-based docking reveals Imidazolidinyl urea as a multitargeted inhibitor for lung cancer: an optimisation followed multi-simulation and in-vitro study
Lung Cancer is one of the deadliest cancers, responsible for more than 1.80 million deaths
annually worldwide, and it is on the priority list of WHO. In the current scenario, when cancer …
annually worldwide, and it is on the priority list of WHO. In the current scenario, when cancer …
Development of new bioactive molecules to treat breast and lung cancer with natural myricetin and its derivatives: A computational and SAR approach
Each biopharmaceutical research and new drug development investigation is targeted at
discovering novel and potent medications for managing specific ailments. Thus, to discover …
discovering novel and potent medications for managing specific ailments. Thus, to discover …
RSK inhibitors as potential anticancer agents: discovery, optimization, and challenges
Ribosomal S6 kinase (RSK) family is a group of serine/threonine kinases, including four
isoforms (RSK1/2/3/4). As a downstream effector of the Ras-mitogen-activated protein …
isoforms (RSK1/2/3/4). As a downstream effector of the Ras-mitogen-activated protein …
RSK1 and RSK2 as therapeutic targets: an up-to-date snapshot of emerging data
AN Spirrison, DA Lannigan - Expert Opinion on Therapeutic …, 2024 - Taylor & Francis
Introduction The four members of the p90 ribosomal S6 kinase (RSK) family are
serine/threonine protein kinases, which are phosphorylated and activated by ERK1/2 …
serine/threonine protein kinases, which are phosphorylated and activated by ERK1/2 …
Reporting multitargeted potency of Tiaprofenic acid against lung cancer: Molecular fingerprinting, MD simulation, and MTT-based cell viability assay studies
Lung Cancer (LC) is among the most death-causing cancers, has caused the most
destruction and is a gender-neutral cancer, and WHO has kept this cancer on its priority list …
destruction and is a gender-neutral cancer, and WHO has kept this cancer on its priority list …
RSK4 confers paclitaxel resistance to ovarian cancer cells, which is resensitized by its inhibitor BI-D1870
Many ovarian cancers initially respond well to chemotherapy, but often become drug-
resistant after several years. Therefore, analysis of drug resistance mechanisms and …
resistant after several years. Therefore, analysis of drug resistance mechanisms and …
Therapeutic targeting of p90 ribosomal S6 kinase
EB Wright, DA Lannigan - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
The Serine/Threonine protein kinase family, p90 ribosomal S6 kinases (RSK) are
downstream effectors of extracellular signal regulated kinase 1/2 (ERK1/2) and are activated …
downstream effectors of extracellular signal regulated kinase 1/2 (ERK1/2) and are activated …