Mutations in the transcriptional regulator, Aire, cause APECED, a polyglandular autoimmune
disease with monogenic transmission. Animal models of APECED have revealed that Aire …

A combination of genetic and immunological features is useful for prediction of autoimmune
diabetes. Patterns of immune response correspond to the progression from a preclinical …

The autoimmune regulator (AIRE) gene is crucial for establishing central immunological
tolerance and preventing autoimmunity. Mutations in AIRE cause a rare autosomal …

The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …

Autoimmune type 1 diabetes is characterized by selective destruction of insulin-secreting
beta cells in the pancreas of genetically susceptible individuals. The mechanisms …

Monogenic autoimmune syndromes provide a rare yet powerful glimpse into the
fundamental mechanisms of immunologic tolerance. Such syndromes reveal not only the …

Since many years immunologists have being tried to answer the tantalizing enigma of
immunological tolerance. Complex mechanisms in both thymus (central tolerance) and …

Type 1 autoimmune polyglandular syndrome (APS1) is a rare autosomal recessive disease,
caused by mutations in the autoimmune regulator gene (AIRE); the encoded Aire protein …

Induction of T cell tolerance in the thymus (central tolerance) is essential for preventing
organ‐specific autoimmunity. This apparent paradox is in part explained by promiscuous …

Aims Type 1 diabetes, as a kind of autoimmune diseases, usually results from the broken-
down of self-tolerance. Autoimmune regulator (Aire), as a transcription factor, induces …