[HTML][HTML] Recent applications of quantitative systems pharmacology and machine learning models across diseases
Quantitative systems pharmacology (QSP) is a quantitative and mechanistic platform
describing the phenotypic interaction between drugs, biological networks, and disease …
describing the phenotypic interaction between drugs, biological networks, and disease …
[HTML][HTML] Two heads are better than one: current landscape of integrating QSP and machine learning: an ISoP QSP SIG white paper by the working group on the …
Quantitative systems pharmacology (QSP) modeling is applied to address essential
questions in drug development, such as the mechanism of action of a therapeutic agent and …
questions in drug development, such as the mechanism of action of a therapeutic agent and …
[图书][B] Uncertainty quantification: theory, implementation, and applications
RC Smith - 2024 - SIAM
Uncertainty quantification serves a central role for simulation-based analysis of physical,
engineering, and biological applications using mechanistic models. From a broad …
engineering, and biological applications using mechanistic models. From a broad …
[HTML][HTML] A QSP model for predicting clinical responses to monotherapy, combination and sequential therapy following CTLA-4, PD-1, and PD-L1 checkpoint blockade
Over the past decade, several immunotherapies have been approved for the treatment of
melanoma. The most prominent of these are the immune checkpoint inhibitors, which are …
melanoma. The most prominent of these are the immune checkpoint inhibitors, which are …
[HTML][HTML] Digital pathology analysis quantifies spatial heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 immune markers in triple-negative breast cancer
Overwhelming evidence has shown the significant role of the tumor microenvironment (TME)
in governing the triple-negative breast cancer (TNBC) progression. Digital pathology can …
in governing the triple-negative breast cancer (TNBC) progression. Digital pathology can …
[HTML][HTML] Virtual clinical trials of anti-PD-1 and anti-CTLA-4 immunotherapy in advanced hepatocellular carcinoma using a quantitative systems pharmacology model
Background Hepatocellular carcinoma (HCC) is the most common form of primary liver
cancer and is the third-leading cause of cancer-related death worldwide. Most patients with …
cancer and is the third-leading cause of cancer-related death worldwide. Most patients with …
Applications of quantitative systems pharmacology in model‐informed drug discovery: perspective on impact and opportunities
EL Bradshaw, ME Spilker, R Zang… - CPT …, 2019 - Wiley Online Library
Quantitative systems pharmacology (QSP) approaches have been increasingly applied in
the pharmaceutical since the landmark white paper published in 2011 by a National …
the pharmaceutical since the landmark white paper published in 2011 by a National …
In silico simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model
The low response rate of immune checkpoint blockade in breast cancer has highlighted the
need for predictive biomarkers to identify responders. While a number of clinical trials are …
need for predictive biomarkers to identify responders. While a number of clinical trials are …
[HTML][HTML] Combination therapy with T cell engager and PD-L1 blockade enhances the antitumor potency of T cells as predicted by a QSP model
Background T cells have been recognized as core effectors for cancer immunotherapy. How
to restore the anti-tumor ability of suppressed T cells or improve the lethality of cytotoxic T …
to restore the anti-tumor ability of suppressed T cells or improve the lethality of cytotoxic T …
[HTML][HTML] A computational model of neoadjuvant PD-1 inhibition in non-small cell lung cancer
Immunotherapy and immune checkpoint blocking antibodies such as anti-PD-1 are
approved and significantly improve the survival of advanced non-small cell lung cancer …
approved and significantly improve the survival of advanced non-small cell lung cancer …