[HTML][HTML] Cardiotoxicity in Acute Myeloid Leukemia in Adults: A Scoping Study

I Konstantinidis, S Tsokkou, S Grigoriadis, L Chrysavgi… - Cancers, 2024 - mdpi.com
Simple Summary This is a scoping study aiming to extensively assess and explore the
degree of cardiotoxicity in patients with Acute Myeloid Leukemia (AML) that can be caused …

An updated overview of the role of CYP450 during xenobiotic metabolization in regulating the acute myeloid leukemia microenvironment

C Sandoval, Y Calle, K Godoy, J Farías - International Journal of …, 2023 - mdpi.com
Oxidative stress is associated with several acute and chronic disorders, including
hematological malignancies such as acute myeloid leukemia, the most prevalent acute …

Recent advance of clinically approved small-molecule drugs for the treatment of myeloid leukemia

ZX Niu, YT Wang, JF Sun, P Nie, P Herdewijn - European Journal of …, 2023 - Elsevier
Myeloid leukemia denotes a hematologic malignancy characterized by aberrant proliferation
and impaired differentiation of blood progenitor cells within the bone marrow. Despite the …

RNA therapeutics in targeting G protein-coupled receptors: Recent advances and challenges

W Yuan, X Shi, LTO Lee - Molecular Therapy-Nucleic Acids, 2024 - cell.com
G protein-coupled receptors (GPCRs) are the major targets of existing drugs for a plethora of
human diseases and dominate the pharmaceutical market. However, over 50% of the …

[HTML][HTML] Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention

BT Baby, AM Kulkarni, PKR Gayam… - Archives of Biochemistry …, 2024 - Elsevier
Hedgehog (Hh) signaling plays a significant role in embryogenesis and several
physiological processes, such as wound healing and organ homeostasis. In a pathological …

[HTML][HTML] 成人急性髓系白血病靶向药物研究进展

刘真娇, 陈林 - Advances in Clinical Medicine, 2023 - hanspub.org
急性髓系白血病(acute myeloid leukemia, AML) 是成人中最常见的白血病, 其预后差, 生存期短,
具有高度异质性和显著的细胞遗传学特征. 近年来随着分子靶向及细胞生物学的发展 …